Gregory Petsko

Gregory A. Petsko (born 1948) is an American biochemist and member of the National Academy of Sciences . He has an endowed professorship at Weill Cornell Medical College , is an adjunct professor at Cornell University , and is a professor emeritus at Brandeis University .

As of 2014 Petsko’s research interests are understanding the biochemical bases or neurological diseases like Alzheimer’s, Parkinson’s, and ALS, Discovering drugs (met name by using structure-based drug design ), dat Could therapeutically affect Those biochemical targets, and seeing ANY resulting drug Candidates tested in humans . He has made key contributions to the field of protein kristallografie .

Education

Petsko was an undergraduate at Princeton University . He RECEIVED a Rhodes Scholarship , and obtained his doctorate from the University of Oxford, supervised by David Chilton Phillips , Studying Triosephosphate isomerase .

Career

Petsko’s independent academic career included stints at Wayne State University , the Massachusetts Institute of Technology , the Max Planck Institute , and, since 1991, Brandeis University , where he is Professor of Biochemistry and of Chemistry and Director of the Rosenstiel Center. He is Past President of the American Society for Biochemistry and Molecular Biology . In April 2010, he was elected to the American Philosophical Society . [1] In 2012, he announced dat he was moving to Weill Cornell Medical College in New York City, where his wife, Laurie Glimcher, had bone appointed Dean. [2] He was appointed at Weill Cornell as the director of the Helen and Robert Appel Alzheimer’s Disease Research Institute and the Arthur J. Mahon Professor of Neurology and Neuroscience at the Feil Family Brain and Mind Research Institute, at Cornell University as Adjunct Professor of Biomedical Engineering, and Retained an appointment at Brandeis as Gyula and Katica Tauber Professor of Biochemistry and Chemistry, Professor. [3] [4]

Research

As of 2014 Petsko’s research interests are understanding the biochemical bases or neurological diseases like Alzheimer’s, Parkinson’s, and ALS, Discovering drugs (met name by using structure-based drug design ) therein Could therapeutically affect Those biochemical targets, and seeing ANY resulting drug Candidates tested in humans . [4] [5]

Petsko’s adjusted research interests [6] port leg in protein kristallografie . He is co-author with Dagmar Ringe or Protein Structure and Function . [7] He is the author or’ll be a monthly column in Genome Biology [8] [9] modelled after an amusing column in Current Biology penned by Sydney Brenner . [10] Petsko is best known for using X-ray kristallografie to solvency important problems in protein function waaronder protein dynamics as a function of temperature and problems in mechanistic enzymology. [11] [12] [13]

At MIT and Brandeis, have Trained a large number of current leaders in structural molecular biology who now harbor leadership roles in science. These personen include:

  • Tom Alber and John Kuriyan , professors at the University of California, Berkeley
  • Barry Stoddard and Roland Strong , faculty at Fred Hutchinson Cancer Research Center
  • Ilme Schlichting , department head at Max Planck Institute for Medical Research
  • Ann Stock , a professor at the Howard Hughes Medical Institute and Rutgers
  • Steven Almo , a professor at Albert Einstein College of Medicine
  • Axel Brunger , professor at Stanford University
  • Elias Lolis , professor at Yale University
  • Dennis Vitkup , professor at Columbia University
  • Charles Brenner , department head at the University of Iowa
  • Karen Allen , professor at Boston University
  • Lynne Howell , a professor at University of Toronto
  • David Rose , a professor at University of Waterloo
  • and Stephen Burley or SGX Pharmaceuticals

References

  1. Jump up^ http://www.brandeis.edu/now/images/petskoaps.html
  2. Jump up^ Tate Herbert for The Justice November 13, 2012Petsko set to leave University for New York City in 2014
  3. Jump up^ Weill Cornell Newsroom. April 16, 2014No Stone Unturned: Interview with Gregory Petsko
  4. ^ Jump up to:a b Petsko Laboratory Homepage
  5. Jump up^ Columbia University Newsroom. April 20, 2014’Chaperone’ compounds offer new approach to Alzheimer’s treatment
  6. Jump up^ List of publicationsfromMicrosoft Academic Search
  7. Jump up^ Petsko, Gregory A. (2008). Protein Structure and Function (Primers in Biology) . Oxford [Oxfordshire]: Oxford University Press. ISBN  0-19-955684-9 .
  8. Jump up^ Petsko, GA (2000). “The Grail problem” . Genome Biology . 1 (1): comment002.comment001-comment002.comment001. doi : 10.1186 / gb-2000-1-1-comment002 . PMC  138,819 . PMID  11104515 .
  9. Jump up^ Petsko, GA (2012). “A case of the flu” . Genome Biology . 13 (2): 146. doi : 10.1186 / gb-2012-13-2-146 . PMC  3334562 . PMID  22364112 .
  10. Jump up^ Brenner, S. (2002). “The worm’s turn.” Current Biology . 12 (21): R713. doi : 10.1016 / s0960-9822 (02) 01241-1 . PMID  12419193 .
  11. Jump up^ Frauenfelder, H .; Petsko, GA; Tsernoglou, D. (1979). “Temperature-dependent X-ray diffraction as a probe of protein structural dynamics”. Nature . 280 (5723): 558-563. doi : 10.1038 / 280558a0 . PMID  460,437 .
  12. Jump up^ Schlichting, I .; Berendzen, J .; Chu, K .; Stock, AM; Maves, SA; Benson, DE; Sweet, RM; Rings, D .; Petsko, GA; Sligar, SG (2000). “The Catalytic Pathway or cytochrome P450cam at Atomic Resolution”. Science . 287 (5458): 1615-1622. doi : 10.1126 / science.287.5458.1615 . PMID  10698731 .
  13. Jump up^ Karplus, M .; Petsko, GA (1990). “Molecular dynamics simulations in biology.” Nature . 347 (6294): 631-639. doi :10.1038 / 347631a0 . PMID  2215695 .