Stephen Friend

Stephen H. Friend MD PhD (born January 10, 1953) is an American physician, scientist, entrepreneur and innovator. He is an authority in the field of cancer biology and a pioneer in the field of the genetics of gene expression, integrate system biology approaches to complex diseases. He is the president, co-founder and director of Sage Bionetworks , [1] [2] [3] a Seattle-based nonprofit organization founded in 2009, dat zorgt the tools and environment to conduct dynamic, large-scale Biomedical research transparently and collaboratively.

Friend convinced dat successful Biomedical research requires the active participation from all stakeholders. [4] He is reimagining the role of Citizens in the research process as equal partners with researchers and is building tools to empower Them to Contribute zowel hun data and expertise as they ‘see fit. He wants to break down the cultural barriers dat hamper progress in research and is a strong advocate for open science. Dr. Friend is actively Engaging the community to crowd-source solutions to complex questions Biomedical through targeted open DREAM analysis challenges. [5] In March 2014 Dr. Friend and Dr. Eric Schadt announced the launch of the Resilience Project , a new crowd-sourced effort to under stand how people with high risk or ontwikkelingslanden serious genetic diseases port stayed healthy, and Possibly discover the “genetic decoder ring” that protect and preventable diseases. [6]

Previously Senior Vice President and Franchise Head for Oncology Research at Merck & Co. Dr. Friend led Merck’s Basic Cancer Research policymaking. Prior to dat Dr. Friend co-founded Rosetta Inpharmatics with Leland H. Hartwell and Leroy Hood in 1996 [7] Much of his research has focused on cancer. [1]


Friend RECEIVED his Bachelor of Arts in philosophy, his Ph.D. in Chemistry and his MD from Indiana University . He did his Pediatric residency at Children’s Hospital of Philadelphia, and his Pediatric Hematology / Oncology Fellowship at Boston Children’s Hospital and the Dana-Farber Cancer Institute . He Trained with Robert Weinberg at Whitehead Institute where he co-led the team dat Cloned the first tumor Suppressor genes in 1986.

Research career

Stephen Friend was on the faculty at Harvard Medical School from 1987 to 1995, the Massachusetts General Hospital from 1990 to 1995, [8] and the University of Washington voordat joining the Fred Hutchinson Cancer Research Center as a Full Member and Chair of Pharmacology in 1995 . Along with Dr. Leland H. Hartwell , Friendster founded and co-led the “Seattle Project, an advanced institute for drug discovery at the Fred Hutchinson Cancer Research Center. The Seattle project’s purpose was to link genetics and drug discovery. While there, Dr. Friend and Hartwell developed a method for Examining large patterns of genes and Showed dat deze expression patterns Could bieden detailed functional snapshots linking yeast and man. Their work mention anything allow directive researchers to Intuit cellular activity rechtstreeks from data as Opposed to using hypothesis-driven, narrative approaches to Biology. In 1997 the Seattle Project Evolved JSON Rosetta Inpharmatics, a for-profit company with the mission together, co-founded with Dr. Leroy Hood . Rosetta developed cutting edge tools to generate and analyseren high-dimensional functional genomics data, matching genetic variation and function to drug response. Under Dr. Friend’s leadership Rosetta became one of the first, and must successful, bioinformatica startups and was acquired by Merck in 2001. Merck integrated the Rosetta approach across the global pharmaceutical enterprise with Dr. Friend Senior Vice President and Franchise Head for Oncology Research, leading Merck’s Basic Cancer Research policymaking in the Oncology Early Discovery and Development Divisions.

Since cloning the first tumor suppressor genes, Dr. Friend indicated with p53 as the cause of Li-Fraumeni Syndrome, co-led the teams dat developed the expression profiles therein underlie the OncotypeDx and MammaPrint assays for breast cancer and led the team dat developed the first HDAC inhibitor Zolinza.

In 2009 thanks to Merck’s generosity with software, data, hardware and staff, Dr. Friend and Dr. Eric Schadt co-founded Sage Bionetworks . Friend wants to create a global integrative bionetwork community where researchers are rewarded for collaborating and sharing hun data, knowledge and insights. Dr. Friend is actively Engaging the community to crowd-source solutions to complex questions Biomedical through targeted open DREAM analysis challenges.

Dr. Friend’s major research interests are: 1. Access Platforms for Building Disease Models 2. Bionetwork Models of Disease 3. Clinical Applications of Checkpoint Controls 4. Tumor Suppressor Genes 5. Molecular Pharmacology 6. Array Technology 7. Genomic Approaches to Drug Discovery


Friend is a Fellow of the American Academy of Arts and Sciences . He has leg a senior advisor to the National Cancer Institute , ARC and verschillende biotechnology companies, and a Trustee of the American Association for Cancer Research . He RECEIVED multiple awards onder welke the Markey Cancer Foundation Research Award, [9] Ernst & Young Health Care Award and was named an Ashoka Fellow at Ashoka: Innovators for the Public . [10]In 2013 he was honored as a White House Champions of Change Recipient for Open Science. [11]

About Sage Bionetworks

Sage Bionetworks ‘ s mission is to encouragement sharing or data and insights as a mechanism of accelerating research while Engaging Citizens and patients more rechtstreeks as partners in the area of Biomedical research. Under Dr. Friend’s leadership, Sage Bionetworks has developed an open-source technology platform, called Synapse, for data-intensive analysis, sharing and reuse, enabling researchers to perform cutting edge computational biology and research. Synapse kunnen researchers to seamlessly and transparently conduct, track and share hun ongoing work – building up living research projects in real time.

Selected bibliography

Stephen Friend has published morethan 130 peer-reviewed papers. A few of These publications include:

  • The Nature paper Describing the isolation of the first tumor suppressor gene [12]
  • Deciphering the functions of p53 in osteosarcoma [13] and other cancers [14]
  • Using gene signatures as predictor of outcome in breast cancer, [15] [16]
  • Observing conserved gene expression patterns across species [17]
  • Leveraging crowd-sourced approach to facility Discoveries [18]
  • Improving predictive molecular models or breast cancer through competition-based analysis challenge [19]
  • The benefits of transparent collaborative research- a real life experience to enable the Cancer Genome Atlas [20]


  1. ^ Jump up to:a b Kaiser, Jocelyn (2012). “Profile Stephen Friend: The Visionary”. Science . 335 (6069): 651-653. doi : 10.1126 / science.335.6069.651 . PMID  22323794 . (subscription required ( help )) .
  2. Jump up^ “Sage Bionetworks Seattle | Directors” . Archived from the original on 2012-02-11.
  3. Jump up^ Staff (2008). “Stephen Friend”. Nature Reviews Drug Discovery . 7 (2): 114. doi : 10.1038 / nrd2509 . (subscription required ( help )) .
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  6. Jump up^ Friend, SH; Schadt, EE (2014). “Clues from the resilient”. Science . 344 (6187): 970-2. Bibkey : 2014Sci … 344..970F . doi : 10.1126 / science.1255648 . PMID  24876479 .
  7. Jump up^ Nelson, B .; Schadt, E. (2009). “Something Wiki this way comes: Stephen Friend and Eric Schadt Reveal hun vision for an open-access platform in medical research.”. Nature . 458 (7234): 13. doi : 10.1038 / 458013a . PMID  19262635 .
  8. Jump up^ Staff. “2014 BIT Brochure” (PDF) . 2014 Bio-IT World Expo . Cambridge Health Tech Institute. p. 4 . Retrieved 15 June 2016 . (registration required ( help )) .
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  12. Jump up^ Friend, SH; Bernards, R .; Rogelj, S .; Weinberg, RA; Rapaport, JM; Albert, DM; Dryja, TP (1986). “A human DNA segment with properties of the genes therein predisposes to retinoblastoma and osteosarcoma”. Nature . 323 (6089): 643-6. Bibkey : 1986Natur.323..643F . doi : 10.1038 / 323643a0 . PMID  2877398 .
  13. Jump up^ Diller L Kassel J. Nelson CE, Gryka MA, Litwak G Gebhardt M Bressac B, Ozturk M, Baker SJ, Vogelstein B; Kassel; Nelson; Gryka; Litwak; Gebhardt; Bressac; Ozturk; Baker; Vogelstein (Nov 1990). “p53 functions as a cell cycle control protein in osteosarcomas” . Mol Cell Biol . 10 (11): 5772-81. doi : 10.1128 / MCB.10.11.5772 . PMC  361,354 . PMID  2233717 .
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  15. Jump up^ Van ‘t Veer, LJ ; Dai, H .; Van De Vijver MJ; Hey, YD; Hart, AA; Bernards, R .; Friend, SH (2003). “Expression profiling predicts outcome in breast cancer” . Breast Cancer Research . 5 (1): 57-8. doi : 10.1186 / bcr562 . PMC  154,139 . PMID  12559048 .
  16. Jump up^ Van De Vijver et al ; Friend, SH; Bernards, R. (2002). “A Gene Expression Signature as a Predictor of Survival in Breast Cancer”. New England Journal of Medicine 347 (25): 1999-2009. doi:10.1056 / NEJMoa021967
  17. Jump up^ Schadt, EE; .; Friend, SH (2003). “Genetics of gene expression surveyed in maize, mouse and man.” Nature 422 (6929): 297. doi:10.1038 / nature01434.
  18. Jump up^ Norman, TC; Bountra, C .; Edwards, AM; Yamamoto, KR; Friend, SH (2011). “Leveraging crowdsourcing to Facilitate the Discovery of New Medicines”. Science Translational Medicine 3 (88): 88mr1. doi:10.1126 / scitranslmed.3002678
  19. Jump up^ Margolin, AA; .; Friend, SH; Stolovitzky, G .; Aparicio, S .; Caldas, C .; Borresen-Dale A. -L. (2013). “Systematic Analysis of Challenge Driven Improvements in Molecular Prognostic Models for Breast Cancer”. Science Translational Medicine 5 (181): 181re1. doi:10.1126 / scitranslmed.3006112
  20. Jump up^ Omberg, L .; Ellrott, K .; Yuan, Y .; Kandoth, C .; Wong, C .; Kellen, MD; Friend, SH; Stuart, J .; Liang, H .; Margolin, AA (2013). “Enabling transparent and collaborative computational analysis of 12 tumor types binnen the Cancer Genome Atlas” . Nature Genetics . 45 (10): 1121-6. doi : 10.1038 / ng.2761 . PMC  3950337 . PMID  24071850 .